212PB Generator for bruk i produksjon av Alpha radioligand terapier

Offentlig prosjektsammendrag

Radioligand therapy (RLT) is a promising form of cancer treatment which uses targeted molecules to carry radioactive isotopes to proteins expressed on tumor cells, delivering lethal radiation to tumors while sparing healthy tissues. Despite growing excitement about Pb212 Alpha Radioligand Therapy (ART), current technology cannot produce Pb212 at commercially relevant scales, hampering further development. ARTBIO is pioneering AlphaDirect, a first-of-its-kind system that offers unique advantages for Pb212 isolation. AlphaDirect is a closed, shoebox size generator that allows Pb212 to be easily generated and used to produce ARTs. It involves a simple process with no liquid separation, resulting in an industry-leading 99.9%+ purity of Pb212, with starting materials derived from nuclear waste material (Th228). The goal for this program is to further develop AlphaDirect technology to enable better avaliability of the important Pb-212 for R&D, clinical and commercial scale production.