Nye uniforme PEG-baserte forbindelser for bruk i medisinske produkter

Offentlig prosjektsammendrag

Polypure is experiencing increased interest for our unique monodisperse products based on polyethylene glycol (PEG) from the pharma industry as well as from academia. The current project is based on ideas sparked from ongoing H2020-projects, and aims to develop new methods for production and analysis of high-molecular weight monodisperse polyethylene glycol (PEG) derivatives for self-assembly nanoparticles for drug delivery, and for example replace the polydisperse PEG-lipid utilised in mRNA vaccines. The project will aim to prepare both PEG lipids and PEG coupled to monodisperse polypropylene glycol (PPG). Currently, only polydisperse or not fully uniform PEG is available on the market and utilised as an ingredient for drug formulations. The project will include scale up from initially gram quantities to between 1 and 100 kg for selected key PEG derivatives.