Robust produksjon av meir potente immunceller til ny kreftbehandling

Offentlig prosjektsammendrag

Cryoimmunotherapy (CryoIT) is a dendritic cell-based cancer therapy with several advantages, in particular its ability to tackle cancer cell heterogeneity. One key component of CryoIT is to manufacture dendritic cells from the patients’ own white blood cells. Current dendritic cell preparations have limitations. More potent therapeutic dendritic cells can be developed. The project has established a semi-robotic system for sterile isolation and production of therapeutic dendritic cells. The system is compatible with different production methods. One method is to isolate patient monocytes that can be differentiated to dendritic cells in culture with several supplements. Another new possibility is to isolate natural dendritic cells that circulate in low numbers in the blood for use in CryoIT, without any cell culture step. Different production methods and supplements will be compared using established assays to select the optimal preparation to be integrated into next generation CryoIT.