Saltaktive nukleaser i nedstrøms prosessering av bionanopartikler

Offentlig prosjektsammendrag

ArcticZymes Technologies (AZT) was the first company to produce salt-tolerant nucleases applied in viral vector manufacturing, and has been part of pioneering the improvement of host cell DNA removal in viral vector manufacturing for gene therapy, vaccines and oncology. AZT has initiated a collaborative research project with the Austrian Centre of Industrial Biotechnology (acib), a globally recognized research center specializing in industrial biotechnology. AZT and acib will unite their respective expertise in enzymology and viral like particle (VLP) processing to devise innovative methodologies aimed at enhancing their purity and scalability. The anticipated outcome of the projects will result in improved protocols and processes for applying ArcticZymes salt-active nucleases in the downstream purification process of VLPs and new knowledge about the degradation and measurement of chromatin DNA in such processes.