NAD+ Precursor – Nicotinamide Riboside Chloride

Offentlig prosjektsammendrag

The physiological effects of NCRl are currently being investigated in many clinical trials, including research into diverse cardiovascular diseases, neural and cognitive functions, metabolic disturbances, muscular and kidney injuries, aging, and chemotherapy. In addition, fundamental research on NR transport and metabolic pathways will further support a rapid translation to effective therapeutic use. The advantages of using NR over alternative NAD+ precursors, including its safety and efficiency, suggest the possible replacement of niacin as a general supplement. Taking nicotinamide riboside can help raise low NAD+ levels. The consumer uses nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer’s disease, obesity, and many other purposes. However, many clinical studies are underway to prove its efficacy. One of the limitations in the commercial exploitation of nicotinamide riboside and its derivatives is that known synthetic methods for preparing nicotinamide riboside and its products have several disadvantages, rendering them unsuitable for scaling up for commercial or industrial use. In the production of food supplements, it is mainly possible to choose a form of isomer and delivery that provides an acceptable shielding of the product from environmental impact. Most fortified foods, however, are moist and often have a more or less acidic environment that is not suitable for the stability of added NRCl. The problem to be solved is how NRCl can be made entirely stable under moist and acidic conditions. Furthermore, we will look at the possibilities of reducing the demands on temperature and lighting conditions. It is plausible that an analog or derivative of NRCl may serve as a better functional group for a key mode of action. This approach, similar to the one adopted in optimizing drugs, has the potential to discover a brand new drug or food supplement.