Liquid Array Detection

Offentlig prosjektsammendrag

Genetic Analysis is a Norwegian biotech company with a dedicated team of scientists with expertise within molecular biology, clinical research and bioinformatics/biostatistics. The company has previously CE-marked and launched the GA-map Dysbiosis test. The test is offered as an IVD version to laboratories in Europe and as "research use only" in the US. Genetic analysis has a production unit producing reagent kits for the Dysbiosis Test as well as an in-house service laboratory facility. The majority of the scientific staff is however working in a dedicated Research and Development team that constantly improves and develops new products for analysis of the human gut microbiota. There is a need for replacing the explorative hypothesis generating next generation sequencing techniques with techniques that only target microorganisms with diagnostic value. GA will develop a novel technology called Liquid Array Detection that allows detection of complex bacterial communities in a single-tube multiplex reaction, which is both simple and cheap. LAD detection is achieved by combining different channels of fluorescence detection and multiple melting profiles per channel. This project will build on GAs expertise in human microbiota testing and the overall aim is to provide novel insight into the causal relationship between microbiota composition and clinical conditions and indications. Ultimately this will enable physicians to provide personalized and targeted treatment to patients.