Improved human free light chain diagnostic immunoassay reagents

Offentlig prosjektsammendrag

Serum FLC measurements are increasingly relevant in the screening for monoclonal gammopathies, prognostic stratification and monitoring of therapy responses. The techniques of gel precipitation are gradually being replaced by turbidimetric platforms. Analytical issues are documented for commercially available sFLC immunoturbidimetric assays related to specificity, sensitivity, linearity, and lot-to-lot and interanalyzer variation. We will address these issues through the astute selection of the antibody and antigens used. The C-LITE project will develop novel specific, and sensitive turbidimetric reagents for sFLC that can be run on open clinical platforms.