Mariana SF Extension

Offentlig prosjektsammendrag

The objective of the project is to create an advanced image-guided flexible catheter platform for bronchoscopy used for diagnosis and treatment of lung cancer. The MARIANA system will consist of three key elements: - DEEP-REACH: Image-guided tip-tracked catheter with lumen and mechanical steering. - DEEP-TRACK: Electromagnetic (wireless) tip and bronchoscopy tracking system - DEEP-VIEW: Image-guidance tool for navigation and cloud-based image processing. The project will result in a more accurate, more effective and less expensive management of early stage lung cancer compared to existing procedures. Increased accuracy will be achieved through significant progress beyond the current state of the art in image-guidance and tracking technology. While currently available technology does not enable real-time diagnosis and therapy, advanced imaging when used in conjunction with instrument tracking has been shown to improve diagnostic outcomes. Our catheter channel enables immediate endoluminal probe therapy using high-impact developmental technologies such as photodynamic therapy, cryotherapy and electrochemotherapy without the need for a separate procedure. The image-guidance platform will reduce biopsy costs by enabling endoluminal approaches to nodules which are now subject to surgical biopsy. Wireless electromagnetic navigation is facilitated with machine-learned predictive software mapping of lumens in the outer airways using the CustusX platform technology. Real-time patient motion tracking will facilitate compensation of tracking errors due to breathing and patient movement. Based on novel lumen extraction algorithms and registration techniques, we will develop and produce a cloud-based software tool for planning and guiding procedures. We envisage significant navigation capabilities beyond the current commercial standard of 6-8 airway branches with endoluminal navigation in up to 12 airway branches.